Types of Lipodystrophy

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Acquired Lipodystrophies lack a genetic form and emerge during a lifetime, often stemming from a significant illness.

Subtypes: 

a.) Acquired Generalized Lipodystrophy (AGL): varying fat loss patterns that can occur over time or very rapidly. Typical symptoms of AGL include severe insulin resistance, metabolic complications, and potential liver issues. People with AGL often experience other autoimmune issues with multiple diagnoses. 

b.) Acquired Partial Lipodystrophy (APL):  leads to progressive fat loss in the upper body and excess fat gain in the lower body. Common symptoms include developing kidney disorders, eye disorders, and autoimmune disorders. 

c.) High Active Antiretroviral Therapy-Induced Lipodystrophy (LD-HIV): arises in HIV patients receiving antiretroviral therapy, causing gradual fat loss in limbs and face. 

d.) Localized Lipodystrophy: involves subcutaneous fat loss in specific body areas, often linked to repeated drug injections eg, insulin.

The most common type of lipodystrophy involves progressive, selective loss of subcutaneous fat, which leads to abnormal fat accumulation in other body areas. FPL is associated with various metabolic complications, including glucose intolerance, high triglycerides, diabetes and pancreatitis. Fat distribution can differ depending on the type of partial lipodystrophy. FPL is a progressive disease that can lead to significant health complications and premature death if not properly diagnosed and managed.  

A rare genetic disorder marked by near-total body fat loss and heightened muscularity. Linked to insulin resistance, glucose intolerance, and diabetes, high triglycerides, pancreatitis, CGL manifests in four subtypes with distinct gene mutations.